Chemistry and Structural Biology of DNA Damage and Biological Consequences

Chemistry and structural biology of DNA damage and biological consequences.

The formation of adducts by the reaction of chemicals with DNA is a critical step for the initiation of carcinogenesis. The structural analysis of various DNA adducts reveals that conformational and chemical rearrangements and interconversions are a common theme. Conformational changes are modulated both by the nature of adduct and the base sequences neighboring the lesion sites. Equilibria bet...

Chemistry and biology of DNA repair.

Numerous agents of endogenous and exogenous origin damage DNA in our genome. There are several DNA-repair pathways that recognize lesions in DNA and remove them through a number of diverse reaction sequences. Defects in DNA-repair proteins are associated with several human hereditary syndromes, which show a marked predisposition to cancer. Although DNA repair is essential for a healthy cell, DN...

synthesis and characterization of potentially biological active cyclometallated organoplatinum(ii) complexes

this work is presented in five parts. in the first part preparation of the starting complex [pt(c^n)cl(dmso)], 1, in which c^n = n(1),c(2?)-chelated, deprotonated 2-phenylpyridine, and dmso = dimethylsulfoxide, and its reaction with 1 equiv of the biphosphine ligands bis(diphenylphosphino)amine, dppa, or bis(diphenylphosphino)methane, dppm, to give the complex [pt(c^n)cl(dppa)], 2, or [pt(c^n)c...

Radiation track and DNA damage

performance of biological system and advanced oxidation processes (aop) treating antibiotic production industrial wastewater

در این مطالعه، عملکرد دو سیستم اکسیداسیون شیمیایی پیشرفته و یک سیستم بیولوژیکی برای حذف آموکسی سیلین در فاضلاب های سنتزیدر غلظت های مشابه با موارد صنعتی مورد بررسی قرار گرفته شدند. مطالعه انجام شده دارای سه بخش متفاوت اکسیداسیون با ازن و اشعه uv، اکسیداسیون با استفاده از نانو فتوکاتالیست tio2 و استفاده از بیوراکتور هوازی لجن فعال با جداکننده های فیزیکی می باشد. در هر بخش، متغیر های متفاوتی متنا...